Prechallenge Antibodies Moderate Disease Expression in Adults Experimentally Exposed to Rhinovirus Strain Hanks

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Prechallenge antibodies moderate disease expression in adults experimentally exposed to rhinovirus strain hanks.

This double-blind study determined the influence of serum neutralizing antibody titers on the rate of infection and magnitude of disease expression after experimental exposure of adult volunteers to rhinovirus strain Hanks (RV-H). A total of 133 healthy volunteers were tested for antibody status, cloistered for a 6-day period, and challenged with RV-H at the end of the first cloister day. On th...

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Prechallenge Antibodies: Moderators of Infection Rate, Signs, and Symptoms in Adults Experimentally Challenged

Author Information From the Department of Pediatric Otolaryngology (C.M.A., W.J.D., C.A.B. J.T.S.) andthe Department of Allergy and Immunology (D.P.S.), Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine; from the Center for Prevention of Disease and Injury (J.M.G.), University of Virginia School of Medicine, Charlottesville; and from the Department of Psychia...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 1998

ISSN: 1058-4838,1537-6591

DOI: 10.1086/514634